All Politics Is Local

All climate is local.

For years scientists have urged national leaders to tackle climate change, based on the assumption that prevention efforts would require the coordinated actions of entire nations to be effective. But as anyone who has watched the past 15 years of international climate negotiations can attest, most countries are still reluctant to take meaningful steps to lower their production of greenhouse gas...

Enzyme/prodrug-based tumor vaccination: all politics (and immunity) are local.

A major focus of gene therapy for cancer has been the effort to introduce into cancer cells a number of foreign genes that encode enzymes that will selectively convert nontoxic prodrugs into toxic compounds, producing high local concentrations that result in tumor cell killing—so-called “suicide” gene therapy. A number of enzyme/prodrug systems have been described [reviewed in (1)], including h...

Academic nepotism – all that glitters is not gold

Dear Editor With increasing emphasis on publications forfaculty recruitment, career advancementand obtaining research grants, the issues relatedto author kinship and academic nepotism havegrown significantly and these probably reflectthe inflationary growth rather than the optimalgrowth warranted due to increasing researchcomplexity. Allesina S (1) measured the fullmagnitude of nepotism in the ...

All arteriogenesis is local? Home boys versus the newcomers.

Versus the Newcomers To the Editor: The article by Khmelewski et al1 raises an important question in the field of arteriogenesis: do circulating (mononuclear) cells play a functional role during the adaptive proliferation of preexistent collateral pathways? Khmelewski et al propose that local vascular macrophages, rather than circulating monocytes, are crucial during early phases of arteriogene...

Where is Urban Politics ?